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Inside a research in breast most cancers cells, the combination of lapatinib, a twin HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented the two HER2 and HER3 phosphorylation induced by INK128 and developed synergistic induction of mobile death in several HER2-good cell strains proof against trastuzumab and lapatinib. In vivoThe mark